25-HYDROXYCHOLESTEROL AND 27-HYDROXYCHOLESTEROL INHIBIT HUMAN ROTAVIRUS INFECTION BY SEQUESTERING VIRAL PARTICLES INTO LATE ENDOSOMES

25-Hydroxycholesterol and 27-hydroxycholesterol inhibit human rotavirus infection by sequestering viral particles into late endosomes

A novel innate immune strategy, involving specific cholesterol oxidation products as effectors, has begun to reveal connections between cholesterol metabolism and immune response against viral infections.Indeed, 25-hydroxycholesterol (25HC) and 27-hydroxycholesterol (27HC), physiologically produced by enzymatic oxidation of cholesterol, act as inhi

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Overexpression of lpxT Gene in Escherichia coli Inhibits Cell Division and Causes Envelope Defects without Changing the Overall Phosphorylation Level of Lipid A

LpxT is an inner membrane protein that transfers a phosphate group from the essential lipid undecaprenyl pyrophosphate (C-55PP) to the lipid A moiety of lipopolysaccharide, generating a lipid A tris-phosphorylated species.The protein is encoded by the non-essential lpxT gene, which is conserved in distantly related Gram-negative bacteria.In this Ey

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Evaluation of Bulk Modulus of Oil System with Hydraulic Line

The aim of the paper is to experimentally measure and ealuate bulk modulus of oil/steel pipe system and oil/hose system.The measurement was performed using experimental device on the basis of a measured body bar pressure difference depending on time.Bulk modulus is evaluated from pressure change with known flow and volume of line.Pressure rise is c

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MetaSSI: A Framework for Personal Data Protection, Enhanced Cybersecurity and Privacy in Metaverse Virtual Reality Platforms

The Metaverse brings together components of parallel processing computing platforms, the digital development of physical systems, cutting-edge machine learning, and virtual identity to uncover a fully digitalized environment with equal properties to the real world.It possesses more rigorous requirements for connection, including safe access and dat

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